Human Eosinophils Release the Lymphocyte and Eosinophil Active Cytokines, RANTES and Lymphocyte Chemoattractant Factor
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چکیده
منابع مشابه
CD4-mediated stimulation of human eosinophils: lymphocyte chemoattractant factor and other CD4-binding ligands elicit eosinophil migration
Lymphocyte chemoattractant factor (LCF) is a tetrameric glycoprotein of 56,000 relative molecular mass produced by activated T lymphocytes. LCF binds to CD4 and has previously been found to stimulate migration of CD4+ lymphocytes and monocytes. Because human eosinophils, like T cells and monocytes, express CD4, we examined functional responses of eosinophils to LCF. Recombinant LCF (rLCF) expre...
متن کاملHuman eosinophil-lymphocyte interactions.
While the eosinophil's effector functions clearly can contribute to the pathogenesis of allergic diseases, the evolutionary benefit to having eosinophils as a distinct class of leukocyte is not clear, especially if one must reconsider the nominally beneficial role of eosinophils in parasite host defense, Eosinophils are equipped to respond to lymphocytes and their cytokines (and not solely the ...
متن کاملCytokines and Lymphocyte Activation
It is well known that the activation of lymphoid cells differ significantly depending on their lineage/subset and differentiation stages. Among the variety of cytokines characterized until today, essentially all the cytokines appear not to be strictly specific to any of the subset of lymphocytes. For example, all the interleukins including IL-2, IL-4 and IL-5 are not specific for B or T lymphoc...
متن کاملTh17 cytokines regulate profibrotic cytokines release by human eosinophils
Rationale Asthma is a chronic inflammatory disorder of the lung airways that is associated with airway remodeling and hyperresponsiveness. One of the most critical structural changes that affect airway functionality is fibrotic tissue deposition within the airway wall. Eosinophils have been proposed in different studies to contribute to the production of several mediators and cytokines, includi...
متن کاملTh17 cytokines induce pro-fibrotic cytokines release from human eosinophils
BACKGROUND Subepithelial fibrosis is one of the most critical structural changes affecting bronchial airway function during asthma. Eosinophils have been shown to contribute to the production of pro-fibrotic cytokines, TGF-β and IL-11, however, the mechanism regulating this process is not fully understood. OBJECTIVE In this report, we investigated whether cytokines associated with inflammatio...
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ژورنال
عنوان ژورنال: International Archives of Allergy and Immunology
سال: 1995
ISSN: 1018-2438,1423-0097
DOI: 10.1159/000237023